Harnessing mesenchymal stem cell secretome: Effect of extracellular matrices on proangiogenic signaling
نویسندگان
چکیده
منابع مشابه
Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease.
The broad repertoire of secreted trophic and immunomodulatory cytokines produced by mesenchymal stem cells (MSCs), generally referred to as the MSC secretome, has considerable potential for the treatment of cardiovascular disease. However, harnessing this MSC secretome for meaningful therapeutic outcomes is challenging due to the limited control of cytokine production following their transplant...
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multipotent mesenchymal stem cells (mscs) are recently found to alter the tumor condition. however their exact role in tumor development is not yet fully unraveled. mscs were established to perform many of their actions through paracrine effect. thus investigation of msc secretome interaction with tumor cells may provide important information for scientists who are attempting to apply stem cell...
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Hematopoietic stem cells (HSCs) are multipotent stem cells, with self-renewal ability as well as ability to generate all blood cells. Mesenchymal stem cells (MSCs) are multipotent stem cells, with self-renewal ability, and capable of differentiating into a variety of cell types. MSCs have supporting effects on hematopoiesis; through direct intercellular communications as well as secreting cytok...
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Mesenchymal Stem Cells (MSCs), often referred to as stromal cells have been the focus in regenerative medicine for their immune suppressive ability, their ability to hone in on the site of injury, their ability to differentiate into multiple cell lines, and ease of cell culture expansion. MSCs have the ability to differentiate into a range of specialized cells of mesodermal origin bone, cartila...
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Valproic acid (2-n-propylpentanoic acid, VPA) is a widely used antiepileptic and anticonvulsant drug. Previous studies have reported that VPA effects osteogenesis in vivo and in vitro, yet it remains unclear whether VPA promotes cell differentiation of osteoblasts derived from mesenchymal cells. The purpose of this study was to clarify the effect of VPA on undifferentiated pluripotent mesenchym...
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ژورنال
عنوان ژورنال: Biotechnology and Bioengineering
سال: 2020
ISSN: 0006-3592,1097-0290
DOI: 10.1002/bit.27272